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Journal of Hazardous Materials|March 24, 2026
Trihexyl phosphate exposure disrupts mitophagy and activates mtDNA-cGAS-STING signaling to drive pyroptosis and steroidogenic impairment in Leydig cellsYinwei Dai, Zhuoqi Chen, Weijian Zhu, et al.
Bioorganic Chemistry|July 3, 2026
Benzalkonium chloride disrupts human placental progesterone synthesis via locking NAD<sup>+</sup> pocket in 3β-Hydroxysteroid dehydrogenase 1 and rat homolog: docking evidence and 3D-QSAR, and experiment risk assessmentNianci Chen, He Zhu, Chuhang Chi, et al.
Endocrinology|January 18, 2002
Expression of 11beta-hydroxylase in rat Leydig cellsGui-Min Wang, Ren-Shan Ge, Syed A Latif, et al.
Pharmacology|May 21, 2016
Effects of Polybrominated Diphenyl Ethers on Rat and Human 11β-Hydroxysteroid Dehydrogenase 1 and 2 ActivitiesXiaomin Chen, Yaoyao Dong, Shuyan Cao, et al.
Ecotoxicology and Environmental Safety|January 31, 2025
Inhibition of FTO expression by thiodiphenol impairs Leydig cell maturation in pubertal male ratsBingru Zhang, Hehua Quan, Chao Wen, et al.
Neuroscience Letters|May 30, 2017
Butylated hydroxyanisole alters rat 5α-reductase and 3α-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesisJingjing Guo, Lili Li, Songyi Zhou, et al.
Reproductive Toxicology (Elmsford, N.Y.)|October 2, 2023
Arbutin inhibits androgen biosynthesis by rat immature Leydig cells in vitroYuanyuan Shan, Yang Yu, Xiaoheng Li, et al.
Frontiers in Endocrinology|February 11, 2020
Dehydroepiandrosterone and Its CYP7B1 Metabolite 7α-Hydroxydehydroepiandrosterone Regulates 11β-Hydroxysteroid Dehydrogenase 1 Directions in Rat Leydig CellsQiqi Zhu, Yaoyao Dong, Xiaoheng Li, et al.
Seminars in Cell & Developmental Biology|May 18, 2021
Stem Leydig cells: Current research and future prospects of regenerative medicine of male reproductive healthXiaoheng Li, Erpo Tian, Yiyan Wang, et al.
Toxicology Letters|May 11, 2020
Effects of in utero exposure to diisodecyl phthalate on fetal testicular cells in ratsSong Zhang, Xiuxiu Chen, Xiaoheng Li, et al.
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