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Bioorganic & Medicinal Chemistry Letters|May 27, 2021
Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5Shaoyi Sun, Qi Jia, Alla Y Zenova, et al.Bioorganic & Medicinal Chemistry|March 15, 2006
The discovery of glycine and related amino acid-based factor Xa inhibitorsJeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, et al.Bioorganic & Medicinal Chemistry Letters|November 23, 2024
Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7Shaoyi Sun, Sultan Chowdhury, Ivan Hemeon, et al.British Journal of Pharmacology|June 26, 2024
The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure controlJames P Johnson, Thilo Focken, Parisa Karimi Tari, et al.Journal of Medicinal Chemistry|December 1, 2018
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic ActivityShaoyi Sun, Qi Jia, Alla Y Zenova, et al.Journal of Medicinal Chemistry|May 9, 2018
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of PainThilo Focken, Sultan Chowdhury, Alla Zenova, et al.Elife|March 2, 2022
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and ratsJ P Johnson, Thilo Focken, Kuldip Khakh, et al.Journal of Medicinal Chemistry|March 8, 2021
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310Brian S Safina, Steven J McKerrall, Shaoyi Sun, et al.Pageof 2