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Nature Biotechnology
|
May 23, 2018
Reversal of siRNA-mediated gene silencing in vivo
Ivan Zlatev, Adam Castoreno, Christopher R Brown, et al.
Nucleic Acids Research
|
July 16, 2021
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo
Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, et al.
Nucleic Acids Research
|
February 12, 2021
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs
Masaaki Akabane-Nakata, Namrata D Erande, Pawan Kumar, et al.
ACS Chemical Biology
|
March 3, 2015
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes
Shigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, et al.
Angewandte Chemie (International Ed. in English)
|
July 12, 2012
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
Muthusamy Jayaraman, Steven M Ansell, Barbara L Mui, et al.
Journal of the American Chemical Society
|
September 23, 2017
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Elise Malek-Adamian, Dale C Guenther, Shigeo Matsuda, et al.
Nucleic Acids Research
|
August 19, 2020
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates
Christopher R Brown, Swati Gupta, June Qin, et al.
Journal of Medicinal Chemistry
|
February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Journal of the American Chemical Society
|
August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
Nucleic Acids Research
|
May 14, 2024
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates
Mikyung Yu, June Qin, Xiumin Liu, et al.
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Search research articles
Search
Showing results (31-40 of 43) with videos related to
Sort By:
Page
of 5
Nature Biotechnology
|
May 23, 2018
Reversal of siRNA-mediated gene silencing in vivo
Ivan Zlatev, Adam Castoreno, Christopher R Brown, et al.
Nucleic Acids Research
|
July 16, 2021
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo
Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, et al.
Nucleic Acids Research
|
February 12, 2021
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs
Masaaki Akabane-Nakata, Namrata D Erande, Pawan Kumar, et al.
ACS Chemical Biology
|
March 3, 2015
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes
Shigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, et al.
Angewandte Chemie (International Ed. in English)
|
July 12, 2012
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
Muthusamy Jayaraman, Steven M Ansell, Barbara L Mui, et al.
Journal of the American Chemical Society
|
September 23, 2017
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Elise Malek-Adamian, Dale C Guenther, Shigeo Matsuda, et al.
Nucleic Acids Research
|
August 19, 2020
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates
Christopher R Brown, Swati Gupta, June Qin, et al.
Journal of Medicinal Chemistry
|
February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Journal of the American Chemical Society
|
August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
Nucleic Acids Research
|
May 14, 2024
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates
Mikyung Yu, June Qin, Xiumin Liu, et al.
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of 5