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Journal of Medicinal Chemistry|October 1, 2025
Beyond Bioisosteres: Impact of Replacing a Benzene Ring with sp3-Rich Three-Dimensional Saturated Bridged Bicyclic Match Pairs on Biotransformation, Metabolic Stability, and Other ADME ProfilesShruti Surendran, Sivashankaran Raju, Naveen Kalyani, et al.Journal of Medicinal Chemistry|March 30, 2026
From Flat to 3D: Replacing Phenyl Rings with Saturated Bridged Bicyclic Mimetics to Mitigate Bioactivation and Optimize ADME Properties and Oral Bioavailability in Reverse Amide OrientationMurugaiah A M Subbaiah, Shruti Surendran, Gaurav Saini, et al.Pageof 2