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Pharmaceutics|January 21, 2023
Consideration of Commercially Available Hepatocytes as Cell Sources for Liver-Microphysiological Systems by Comparing Liver CharacteristicsShinichiro Horiuchi, Yukie Kuroda, Yuji Komizu, et al.
Archives of Toxicology|May 16, 2024
Formation of functional, extended bile canaliculi, and increased bile acid production in sandwich-cultured human cryopreserved hepatocytes using commercially available culture mediumShinichiro Horiuchi, Yukie Kuroda, Ryota Oyafuso, et al.
The Journal of Toxicological Sciences|January 15, 2016
Upregulations of metallothionein gene expressions and tolerance to heavy metal toxicity by three dimensional cultivation of HepG2 cells on VECELL 3-D insertsTakashi Kubo, Yukie Kuroda, Shinichiro Horiuchi, et al.
Plos One|December 23, 2024
Examination of common culture medium for human hepatocytes and engineered heart tissue: Towards an evaluation of cardiotoxicity associated with hepatic drug metabolism in vitroShinichiro Horiuchi, Nanae Koda, Yui Ikeda, et al.
The Journal of Toxicological Sciences|April 30, 2023
Construction of extended and functional bile canaliculi using long-term sandwich-cultured cryopreserved human hepatocytes and the application of hepatocytes for predicting the biliary excretion of pharmaceutical and food-related compoundsTakashi Kitaguchi, Shinichiro Horiuchi, Yukie Kuroda, et al.
Scientific Reports|September 7, 2022
Construction of a culture protocol for functional bile canaliculi formation to apply human iPS cell-derived hepatocytes for cholestasis evaluationShinichiro Horiuchi, Yukie Kuroda, Ryota Oyafuso, et al.
NAM Journal|July 12, 2026
An oxygen-permeable, stirrer-pump-integrated liver-heart microphysiological system enables time-resolved analysis in PK-PD relationships of metabolism-dependent cardiotoxicityShinichiro Horiuchi, Kiyoshi Oka, Kenta Shinha, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|November 12, 2025
Stable and functional human intestinal epithelium derived from induced pluripotent stem cellsJunlong Chen, So Kuramochi, Shinichiro Horiuchi, et al.
Stem Cell Research & Therapy|January 16, 2024
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cellsJunLong Chen, Shinichiro Horiuchi, So Kuramochi, et al.
European Journal of Cell Biology|June 18, 2025
Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory studyHiroko Toyoda, Ayaka Nozue, Yuki Nishida, et al.
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