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Shiva Malek

Showing results (11-20 of 56) with videos related to

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Nature Reviews. Drug Discovery|October 21, 2020
Author Correction: RAS-targeted therapies: is the undruggable drugged?Amanda R Moore, Scott C Rosenberg, Frank McCormick, et al.
The Journal of Biological Chemistry|April 11, 2003
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complexShiva Malek, De-Bin Huang, Tom Huxford, et al.
Assay and Drug Development Technologies|May 21, 2010
A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascadeSreemathy Ramaswamy, Ivana Yen, Steve Sideris, et al.
Biochemistry|September 24, 2020
Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase ActivationNicholas P D Liau, Avinashnarayan Venkatanarayan, John G Quinn, et al.
Molecular Cancer Therapeutics|September 17, 2013
Identification of preferred chemotherapeutics for combining with a CHK1 inhibitorYang Xiao, Judi Ramiscal, Kaska Kowanetz, et al.
Bioorganic & Medicinal Chemistry Letters|August 13, 2013
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitorsWendy Lee, Daniel F Ortwine, Philippe Bergeron, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2014
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1Lewis Gazzard, Brent Appleton, Kerry Chapman, et al.
Cancer Discovery|December 12, 2012
Noncovalent wild-type-sparing inhibitors of EGFR T790MHo-June Lee, Gabriele Schaefer, Timothy P Heffron, et al.
Nature Structural & Molecular Biology|January 29, 2020
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerizationNicholas P D Liau, Timothy J Wendorff, John G Quinn, et al.
Cancer Cell|August 27, 2014
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signalingJacob R Haling, Jawahar Sudhamsu, Ivana Yen, et al.
Pageof 6

Showing results (11-20 of 56) with videos related to

Sort By:
Pageof 6
Nature Reviews. Drug Discovery|October 21, 2020
Author Correction: RAS-targeted therapies: is the undruggable drugged?Amanda R Moore, Scott C Rosenberg, Frank McCormick, et al.
The Journal of Biological Chemistry|April 11, 2003
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complexShiva Malek, De-Bin Huang, Tom Huxford, et al.
Assay and Drug Development Technologies|May 21, 2010
A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascadeSreemathy Ramaswamy, Ivana Yen, Steve Sideris, et al.
Biochemistry|September 24, 2020
Dimerization Induced by C-Terminal 14-3-3 Binding Is Sufficient for BRAF Kinase ActivationNicholas P D Liau, Avinashnarayan Venkatanarayan, John G Quinn, et al.
Molecular Cancer Therapeutics|September 17, 2013
Identification of preferred chemotherapeutics for combining with a CHK1 inhibitorYang Xiao, Judi Ramiscal, Kaska Kowanetz, et al.
Bioorganic & Medicinal Chemistry Letters|August 13, 2013
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitorsWendy Lee, Daniel F Ortwine, Philippe Bergeron, et al.
Bioorganic & Medicinal Chemistry Letters|December 3, 2014
Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1Lewis Gazzard, Brent Appleton, Kerry Chapman, et al.
Cancer Discovery|December 12, 2012
Noncovalent wild-type-sparing inhibitors of EGFR T790MHo-June Lee, Gabriele Schaefer, Timothy P Heffron, et al.
Nature Structural & Molecular Biology|January 29, 2020
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerizationNicholas P D Liau, Timothy J Wendorff, John G Quinn, et al.
Cancer Cell|August 27, 2014
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signalingJacob R Haling, Jawahar Sudhamsu, Ivana Yen, et al.
Pageof 6