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Proceedings of the National Academy of Sciences of the United States of America|July 7, 2025
DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancersRui Sun, Peng Jiang, Zhijun Wang, et al.
The Journal of Clinical Investigation|July 1, 2025
Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loopXiangyu Zeng, Fei Zhao, Xinyi Tu, et al.
Nature Communications|April 13, 2021
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signalingGuijie Guo, Ming Gao, Xiaochen Gao, et al.
DNA Repair|February 16, 2021
USP13 regulates the replication stress response by deubiquitinating TopBP1Wootae Kim, Fei Zhao, Huanyao Gao, et al.
Nature|October 8, 2025
KCTD10 is a sensor for co-directional transcription-replication conflictsJake A Kloeber, Bin Chen, Guangchao Sun, et al.
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy|April 18, 2024
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapyQin Zhou, Xinyi Tu, Xiaonan Hou, et al.
Molecular Cell|February 28, 2023
SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topologyJinzhou Huang, Chenming Wu, Jake A Kloeber, et al.
The Journal of Clinical Investigation|July 7, 2026
ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppressionXinyi Tu, Xiangyu Zeng, Yaoliang Sun, et al.
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