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Cell Reports. Medicine|June 7, 2021
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeysShu-Chen Lu, Michelle Chen, Larissa Atangan, et al.Nature Metabolism|February 5, 2024
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settingsMurielle M Véniant, Shu-Chen Lu, Larissa Atangan, et al.Journal of Medicinal Chemistry|April 6, 2026
Discovery of AMG 133, a Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonist and Glucagon-Like Peptide 1 Receptor Agonist Antibody-Drug Conjugate for the Treatment of ObesityBin Wu, James R Falsey, Chawita Netirojjanakul, et al.Nature Metabolism|April 29, 2025
GIPR-Ab/GLP-1 peptide-antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese miceClarissa M Liu, Elizabeth A Killion, Rola Hammoud, et al.Science Translational Medicine|December 21, 2018
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical modelsElizabeth A Killion, Jinghong Wang, Junming Yie, et al.Pageof 2