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Experimental Cell Research|May 8, 2020
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemiaCheng Chen, Li Wang, Lili Li, et al.European Journal of Pharmacology|May 10, 2023
Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatmentAoli Wang, Juan Liu, Xixiang Li, et al.Acta Pharmacologica Sinica|December 16, 2024
Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activationLe-Jin Yan, Shuang Qi, Chao Wu, et al.Journal of Medicinal Chemistry|August 29, 2022
Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 DiabetesYun Wu, Ziping Qi, Beilei Wang, et al.European Journal of Medicinal Chemistry|September 19, 2020
Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistant mutantsBeilei Wang, Wentao Zhang, Xuesong Liu, et al.Journal of Medicinal Chemistry|October 19, 2021
Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell LymphomasBin Zhou, Xiaofei Liang, Husheng Mei, et al.Journal of Neurology|March 12, 2022
Basilar artery on computed tomography angiography score and clinical outcomes in acute basilar artery occlusionKangjia Song, Fengli Li, Mingchao Shi, et al.Biological Psychiatry|May 12, 2019
A-Kinase Anchoring Protein 150 and Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint StressHai-Yun Zhou, Jin-Gang He, Zhuang-Li Hu, et al.Cerebral Cortex (New York, N.Y. : 1991)|March 10, 2018
miR-214-3p Targets β-Catenin to Regulate Depressive-like Behaviors Induced by Chronic Social Defeat Stress in MiceZhi-Fang Deng, Hui-Ling Zheng, Jian-Guo Chen, et al.Journal of Medicinal Chemistry|April 15, 2016
Discovery of N-(3-((1-Isonicotinoylpiperidin-4-yl)oxy)-4-methylphenyl)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)Qiang Wang, Feiyang Liu, Beilei Wang, et al.Pageof 15