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Journal of Medicinal Chemistry|July 20, 2026
From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor DiscoveryMinghui Yu, Shuangtian Tang, Lijuan Huang, et al.
Journal of Medicinal Chemistry|January 23, 2026
Discovery of SY-589, a Highly Potent and Orally Bioavailable Polθ Helicase Inhibitor for the Treatment of HR-Deficient TumorsChongxun Ge, Dazhi Feng, Song Shi, et al.
Chemical Science|August 6, 2025
Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacyDazhi Feng, Xinnan Li, Junkai Liu, et al.
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