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Human Molecular Genetics|September 26, 2013
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic miceNicolas Casadei, Anne-Maria Pöhler, Cristina Tomás-Zapico, et al.
Neurobiology of Disease|July 20, 2011
Olfactory neuron-specific expression of A30P α-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stagesSilke Nuber, Elisabeth Petrasch-Parwez, Oscar Arias-Carrión, et al.
JCI Insight|June 3, 2025
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson miceSilke Nuber, Harrison Hsiang, Esra'a Keewan, et al.
Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics|April 21, 2022
A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein ToxicitySilke Nuber, Chee Yeun Chung, Daniel F Tardiff, et al.
Neurobiology of Aging|January 21, 2015
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectorsAnke Van der Perren, Jaan Toelen, Cindy Casteels, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|March 7, 2008
Neurodegeneration and motor dysfunction in a conditional model of Parkinson's diseaseSilke Nuber, Elisabeth Petrasch-Parwez, Beate Winner, et al.
Brain : a Journal of Neurology|February 16, 2013
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic ratsSilke Nuber, Florian Harmuth, Zacharias Kohl, et al.
NPJ Parkinson'S Disease|January 16, 2023
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activityNagendran Ramalingam, Shan-Xue Jin, Tim E Moors, et al.
Molecular Cell|December 12, 2018
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson TreatmentSaranna Fanning, Aftabul Haque, Thibaut Imberdis, et al.
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