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Journal of Medicinal Chemistry|November 15, 2021
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase InhibitorsDennis X Hu, Snahel Patel, Huifen Chen, et al.Journal of Medicinal Chemistry|November 21, 2014
8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitorsAllen A Thomas, Kevin W Hunt, Brad Newhouse, et al.Clinical Proteomics|January 2, 2019
The plasma peptides of ovarian cancerJaimie Dufresne, Pete Bowden, Thanusi Thavarajah, et al.ACS Medicinal Chemistry Letters|September 18, 2024
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1John C Tellis, BinQing Wei, Michael Siu, et al.Journal of Medicinal Chemistry|March 30, 2013
Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher speciesKevin W Hunt, Adam W Cook, Ryan J Watts, et al.Bioorganic & Medicinal Chemistry Letters|April 15, 2019
Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signalingMark Zak, Emily J Hanan, Patrick Lupardus, et al.Journal of Medicinal Chemistry|January 9, 2014
Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous systemAllen A Thomas, Kevin W Hunt, Matthew Volgraf, et al.Science Translational Medicine|August 18, 2017
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative diseaseClaire E Le Pichon, William J Meilandt, Sara Dominguez, et al.Journal of Medicinal Chemistry|October 24, 2014
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration modelsSnahel Patel, Frederick Cohen, Brian J Dean, et al.Journal of Medicinal Chemistry|March 2, 2026
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12CMatthew L Landry, Sushant Malhotra, Maureen Beresini, et al.Pageof 36