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RSC Medicinal Chemistry|December 22, 2022
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinatesS Paul Jones, James D Firth, Mary C Wheldon, et al.
Journal of Medicinal Chemistry|July 13, 2026
X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1)Xinyu Wang, William T W Butler, James R Donald, et al.
SLAS Discovery : Advancing Life Sciences R & D|December 26, 2019
Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain InteractionsAlexander N Phillipou, Charles S Lay, Charlotte E Carver, et al.
Journal of Medicinal Chemistry|July 14, 2021
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) InhibitorsSimon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, et al.
Journal of Medicinal Chemistry|March 21, 2024
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional DegradersSimon C C Lucas, Afshan Ahmed, S Neha Ashraf, et al.
Journal of Medicinal Chemistry|August 10, 2019
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit QualificationPaul Bamborough, Chun-Wa Chung, Emmanuel H Demont, et al.
Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.
Journal of Medicinal Chemistry|September 18, 2024
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 InhibitorsSimon C C Lucas, J Henry Blackwell, Ulf Börjesson, et al.
ACS Medicinal Chemistry Letters|August 20, 2025
Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library ScreenSimon C C Lucas, Alexander G Milbradt, Jason Breed, et al.
Journal of Medicinal Chemistry|December 23, 2025
Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular ToolJ Henry Blackwell, Simon C C Lucas, Giovanni Battocchio, et al.
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