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Nucleic Acids Research|February 10, 2017
Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecanCornelia Meisenberg, Mohamed E Ashour, Lamia El-Shafie, et al.
European Journal of Medicinal Chemistry|November 7, 2017
African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidaseRyan A West, Oran G O'Doherty, Trevor Askwith, et al.
Bioorganic & Medicinal Chemistry Letters|December 17, 2008
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part IISimon E Ward, Peter Eddershaw, Sean T Flynn, et al.
European Journal of Medicinal Chemistry|September 27, 2016
Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitorsOraphan Phuangsawai, Paul Beswick, Siriluk Ratanabunyong, et al.
Bioorganic & Medicinal Chemistry Letters|February 1, 2022
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discoveryFiona Scott, Angela M Fala, Jessica E Takarada, et al.
Frontiers in Cell and Developmental Biology|October 30, 2023
Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivativesMarco Derudas, Molly O'Reilly, Nerissa K Kirkwood, et al.
Journal of Medicinal Chemistry|April 25, 2008
Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonistsSimon E Ward, Peter J Eddershaw, Claire M Scott, et al.
Oncotarget|August 27, 2016
A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain constructCory A Ocasio, Mohan B Rajasekaran, Sarah Walker, et al.
Journal of Psychopharmacology (Oxford, England)|November 27, 2019
Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profileSimon E Ward, Mark H Harries, Laura Aldegheri, et al.
Bioorganic & Medicinal Chemistry Letters|November 30, 2006
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitorsPeter J Lovell, Frank E Blaney, Caroline J Goodacre, et al.
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