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Communications Biology|April 12, 2022
Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemaseChloe R Koulouris, Sian E Gardiner, Tessa K Harris, et al.European Journal of Medicinal Chemistry|March 13, 2024
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinasesScott H Henderson, Fiona J Sorrell, James M Bennett, et al.Journal of Medicinal Chemistry|October 7, 2022
Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular ActivityRoss Collins, Hyunah Lee, D Heulyn Jones, et al.Journal of Medicinal Chemistry|August 3, 2021
Discovery and Characterization of Selective and Ligand-Efficient DYRK InhibitorsScott H Henderson, Fiona Sorrell, James Bennett, et al.British Journal of Pharmacology|December 24, 2016
Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulatorSimon E Ward, Paul Beswick, Novella Calcinaghi, et al.Journal of Medicinal Chemistry|August 6, 2025
Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK InhibitorsAlex G Baldwin, David W Foley, D Heulyn Jones, et al.Elife|March 1, 2021
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome proteinXiangrong Chen, Yusuf I Ali, Charlotte El Fisher, et al.Iscience|September 21, 2023
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesisJingying Zhou, Huanyu Wang, Ting Shu, et al.JCI Insight|December 22, 2017
Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell deathEmma J Kenyon, Nerissa K Kirkwood, Siân R Kitcher, et al.Journal of Medicinal Chemistry|November 9, 2010
Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonistColin P Leslie, Matteo Biagetti, Silvia Bison, et al.Pageof 6