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Bioorganic & Medicinal Chemistry Letters|March 29, 2014
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinaseSteve Wenglowsky, Li Ren, Jonas Grina, et al.Journal of Medicinal Chemistry|June 2, 2015
Structure-Guided Design of Group I Selective p21-Activated Kinase InhibitorsJames J Crawford, Wendy Lee, Ignacio Aliagas, et al.Bioorganic & Medicinal Chemistry Letters|April 27, 2012
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinaseLi Ren, Kateri A Ahrendt, Jonas Grina, et al.Journal of Medicinal Chemistry|September 7, 2022
Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 InhibitorsUpendra Argikar, Markus Blatter, Dallas Bednarczyk, et al.Bioorganic & Medicinal Chemistry Letters|August 2, 2011
Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationshipsSteve Wenglowsky, Kateri A Ahrendt, Alex J Buckmelter, et al.Journal of Medicinal Chemistry|October 12, 2011
Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoformTimothy P Heffron, Binqing Wei, Alan Olivero, et al.Bioorganic & Medicinal Chemistry Letters|March 30, 2010
Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitorTimothy P Heffron, Megan Berry, Georgette Castanedo, et al.Journal of Medicinal Chemistry|January 10, 2024
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal MelanomaMichael Visser, Julien P N Papillon, Michael Luzzio, et al.Journal of Medicinal Chemistry|May 18, 2016
Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology InsightB Barry Touré, John Giraldes, Troy Smith, et al.Molecular Cancer Therapeutics|August 5, 2020
The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal MelanomaFlorencia Rago, GiNell Elliott, Ailing Li, et al.Pageof 3