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Bioorganic & Medicinal Chemistry|June 5, 2007
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activityJoe A Tran, Fabio C Tucci, Wanlong Jiang, et al.Journal of Medicinal Chemistry|October 9, 2007
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexiaChen Chen, Wanlong Jiang, Fabio Tucci, et al.Bioorganic & Medicinal Chemistry Letters|May 23, 2022
Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinismJian Zhao, Shimiao Wang, Sun Hee Kim, et al.Bioorganic & Medicinal Chemistry|April 18, 2008
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonistsChen Chen, Fabio C Tucci, Wanlong Jiang, et al.Journal of Medicinal Chemistry|November 13, 2007
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptorJoe A Tran, Wanlong Jiang, Fabio C Tucci, et al.Bioorganic & Medicinal Chemistry Letters|August 16, 2005
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazinesFabio C Tucci, Nicole S White, Stacy Markison, et al.Bioorganic & Medicinal Chemistry Letters|March 11, 2008
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonistsXiaohu Zhang, Jaimie K Rueter, Yongsheng Chen, et al.Journal of Medicinal Chemistry|January 15, 2008
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacyDeborah H Slee, Xiaohu Zhang, Manisha Moorjani, et al.Journal of Medicinal Chemistry|March 1, 2008
2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituentsDeborah H Slee, Yongsheng Chen, Xiaohu Zhang, et al.Journal of Medicinal Chemistry|October 25, 2008
Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's diseaseXiaohu Zhang, John E Tellew, Zhiyong Luo, et al.Pageof 4