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Nucleic Acid Therapeutics|June 27, 2020
Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two MechanismsAdam J Pollak, Justin H Hickman, Xue-Hai Liang, et al.
Nucleic Acids Research|February 5, 2016
RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machineryWalt F Lima, Cheryl L De Hoyos, Xue-hai Liang, et al.
Nucleic Acids Research|September 2, 2020
Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activityXue-Hai Liang, Joshua G Nichols, Cheryl L De Hoyos, et al.
Nucleic Acids Research|February 12, 2021
Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteinsLingdi Zhang, Timothy A Vickers, Hong Sun, et al.
Nucleic Acid Therapeutics|June 4, 2019
Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into CellsShiyu Wang, Nickolas Allen, Thazha P Prakash, et al.
Plos One|July 30, 2014
Defining the factors that contribute to on-target specificity of antisense oligonucleotidesWalt F Lima, Timothy A Vickers, Josh Nichols, et al.
Nature Biotechnology|March 1, 2017
Cellular uptake and trafficking of antisense oligonucleotidesStanley T Crooke, Shiyu Wang, Timothy A Vickers, et al.
Nucleic Acids Research|May 28, 2014
TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cellsXue-hai Liang, Wen Shen, Hong Sun, et al.
Plos One|March 14, 2017
Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translationWen Shen, Xue-Hai Liang, Hong Sun, et al.
Plos One|October 22, 2014
Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potencyTimothy A Vickers, Susan M Freier, Huynh-Hoa Bui, et al.
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