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Molecular Pharmacology|October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activityAlice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
Bioorganic & Medicinal Chemistry Letters|January 30, 2007
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformationShaun R Stauffer, Matthew G Stanton, Alison R Gregro, et al.
Neuron|May 22, 2025
Machine learning identification of enhancers in the rhesus macaque genomeJing He, BaDoi N Phan, Willa G Kerkhoff, et al.
Leukemia|November 25, 2018
JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activationJulia Czech, Sabrina Cordua, Barbora Weinbergerova, et al.
Blood|March 13, 2012
Regulation of acute graft-versus-host disease by microRNA-155Parvathi Ranganathan, Catherine E A Heaphy, Stefan Costinean, et al.
Schizophrenia Research|September 14, 2013
Issues and perspectives in designing clinical trials for negative symptoms in schizophreniaStephen R Marder, Larry Alphs, Ion-George Anghelescu, et al.
British Journal of Haematology|November 27, 2023
Real-world outcomes following third or subsequent lines of therapy: A Danish population-based study on 189 patients with relapsed/refractory large B-cell lymphomasAhmed Ludvigsen Al-Mashhadi, Lasse Hjort Jakobsen, Peter Brown, et al.
Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.
ACS Medicinal Chemistry Letters|July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting SchizophreniaSusana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.
Bioorganic & Medicinal Chemistry Letters|December 20, 2015
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophreniaSusana Conde-Ceide, Jesús Alcázar, Sergio A Alonso de Diego, et al.
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