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Molecular Pharmaceutics|June 27, 2020
Cytochrome-P450-Mediated Drug-Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification SystemStefanus J Steyn, Manthena V S Varma
Expert Opinion on Drug Metabolism & Toxicology|March 18, 2010
Assessment of in silico models for fraction of unbound drug in human liver microsomesHua Gao, Stefanus J Steyn, George Chang, et al.
ACS Chemical Neuroscience|June 13, 2018
Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on d-Alanine Metabolism in DogsMichael Popiolek, Brendan Tierney, Stefanus J Steyn, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Strategic use of plasma and microsome binding to exploit in vitro clearance in early drug discoveryGeorge Chang, Stefanus J Steyn, John P Umland, et al.
Pharmaceutical Research|July 10, 2015
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)Manthena V Varma, Stefanus J Steyn, Charlotte Allerton, et al.
Journal of Biochemical and Biophysical Methods|January 20, 2005
Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2alpha) cells, a simple and rapid in situ assay to investigate mitochondrial toxinsStefanus J Steyn, Daniël J Pieterse, Lodewyk J Mienie, et al.
The AAPS Journal|May 24, 2014
Permeability comparison between hepatocyte and low efflux MDCKII cell monolayerRui Li, Yi-An Bi, Yurong Lai, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 26, 2013
A perspective on the prediction of drug pharmacokinetics and disposition in drug research and developmentLi Di, Bo Feng, Theunis C Goosen, et al.
Neurotoxicity Research|June 28, 2003
Studies on the interactions of tobacco leaf and tobacco smoke constituents and monoamine oxidaseKay Castagnoli, Stefanus J Steyn, Geraldine Magnin, et al.
Journal of Medicinal Chemistry|January 15, 2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass eliminationManthena V S Varma, R Scott Obach, Charles Rotter, et al.
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