Stefanus J Steyn - JoVE Visualize

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Biochemistry|December 14, 2016

Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor ActivationMichael Popiolek, David P Nguyen, Veronica Reinhart, et al.

Molecular Pharmaceutics|April 12, 2012

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discoveryManthena V Varma, Iain Gardner, Stefanus J Steyn, et al.

ACS Chemical Neuroscience|November 28, 2018

Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of XanomelineCatherine A Thorn, Joshua Moon, Clinton A Bourbonais, et al.

Pharmaceutical Research|December 29, 2023

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig ModelManfred Bodenlenz, Thean Yeoh, Gabriel Berstein, et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 26, 2025

Applications of contemporary tools to measure plasma protein binding of targeted protein degradersMark Niosi, Sam Zhang, Woodrow Burchett, et al.

The Journal of Biological Chemistry|June 17, 2015

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced NeurodegenerationJoão P L Daher, Hisham A Abdelmotilib, Xianzhen Hu, et al.

Bioorganic & Medicinal Chemistry Letters|August 13, 2014

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffoldPaul Galatsis, Jaclyn L Henderson, Bethany L Kormos, et al.

Journal of Medicinal Chemistry|October 18, 2022

Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography LigandZhen Chen, Jiahui Chen, Laigao Chen, et al.

Journal of Medicinal Chemistry|October 30, 2014

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitorJaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, et al.

Bioorganic & Medicinal Chemistry Letters|January 14, 2015

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilinMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.

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Showing results (11-20 of 34) with videos related to

Sort By:

Pageof 4

Biochemistry|December 14, 2016

Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor ActivationMichael Popiolek, David P Nguyen, Veronica Reinhart, et al.

Molecular Pharmaceutics|April 12, 2012

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discoveryManthena V Varma, Iain Gardner, Stefanus J Steyn, et al.

ACS Chemical Neuroscience|November 28, 2018

Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of XanomelineCatherine A Thorn, Joshua Moon, Clinton A Bourbonais, et al.

Pharmaceutical Research|December 29, 2023

Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig ModelManfred Bodenlenz, Thean Yeoh, Gabriel Berstein, et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 26, 2025

Applications of contemporary tools to measure plasma protein binding of targeted protein degradersMark Niosi, Sam Zhang, Woodrow Burchett, et al.

The Journal of Biological Chemistry|June 17, 2015

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced NeurodegenerationJoão P L Daher, Hisham A Abdelmotilib, Xianzhen Hu, et al.

Bioorganic & Medicinal Chemistry Letters|August 13, 2014

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffoldPaul Galatsis, Jaclyn L Henderson, Bethany L Kormos, et al.

Journal of Medicinal Chemistry|October 18, 2022

Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography LigandZhen Chen, Jiahui Chen, Laigao Chen, et al.

Journal of Medicinal Chemistry|October 30, 2014

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitorJaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, et al.

Bioorganic & Medicinal Chemistry Letters|January 14, 2015

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilinMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.

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