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Journal of Medicinal Chemistry|June 10, 2017
Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist ActivityJennifer E Davoren, Michelle Garnsey, Betty Pettersen, et al.Cancer Research|October 19, 2007
Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitorJitesh P Jani, Richard S Finn, Mary Campbell, et al.Journal of Medicinal Chemistry|May 15, 2009
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitorsAllen J Duplantier, Stacey L Becker, Michael J Bohanon, et al.Neuropharmacology|July 19, 2011
Modulation of NMDA receptor function by inhibition of D-amino acid oxidase in rodent brainChristine A Strick, Cheryl Li, Liam Scott, et al.Journal of Medicinal Chemistry|June 18, 2024
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine ReceptorChristopher R Butler, Michael Popiolek, Laura A McAllister, et al.Medchemcomm|August 16, 2018
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacyMartin Pettersson, Douglas S Johnson, Danica A Rankic, et al.ACS Medicinal Chemistry Letters|May 26, 2015
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic StabilityMartin Pettersson, Douglas S Johnson, John M Humphrey, et al.Bioorganic & Medicinal Chemistry Letters|December 4, 2015
Design and optimization of selective azaindole amide M1 positive allosteric modulatorsJennifer E Davoren, Steven V O'Neil, Dennis P Anderson, et al.Bioorganic & Medicinal Chemistry Letters|June 9, 2012
Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptorDaniel W Kung, Steven B Coffey, Ryan M Jones, et al.Journal of Medicinal Chemistry|June 9, 2016
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side EffectsJennifer E Davoren, Che-Wah Lee, Michelle Garnsey, et al.Pageof 4