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Expert Opinion on Drug Discovery|May 27, 2014
Discovery and preclinical development of vismodegibStephen E Gould, Jennifer A Low, James C Marsters, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 1, 2012
Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical responseHarvey Wong, Edna F Choo, Bruno Alicke, et al.
Immunity|March 6, 2016
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint BlockadePeter J R Ebert, Jeanne Cheung, Yagai Yang, et al.
Journal of Medicinal Chemistry|March 29, 2011
Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)Anthony M Giannetti, Harvey Wong, Gerrit J P Dijkgraaf, et al.
Cancer Research|December 3, 2010
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistanceGerrit J P Dijkgraaf, Bruno Alicke, Lasse Weinmann, et al.
Nature|August 30, 2008
A paracrine requirement for hedgehog signalling in cancerRobert L Yauch, Stephen E Gould, Suzie J Scales, et al.
The New England Journal of Medicine|September 4, 2009
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Charles M Rudin, Christine L Hann, John Laterra, et al.
Bioorganic & Medicinal Chemistry Letters|August 21, 2014
Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitorsLan Wang, Mark Stanley, Jason W Boggs, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 18, 2013
Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonistHarvey Wong, Stephen E Gould, Nageshwar Budha, et al.
ACS Medicinal Chemistry Letters|April 21, 2016
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTORTimothy P Heffron, Chudi O Ndubaku, Laurent Salphati, et al.
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