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Journal of Medicinal Chemistry|January 21, 2015
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2Li Ren, Jonas Grina, David Moreno, et al.Toxicological Sciences : an Official Journal of the Society of Toxicology|July 31, 2012
Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysisHarvey Wong, Nageshwar R Budha, Kristina West, et al.Science (New York, N.Y.)|September 4, 2009
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastomaRobert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, et al.Journal of Medicinal Chemistry|September 6, 2012
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase αTimothy P Heffron, Laurent Salphati, Bruno Alicke, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 18, 2016
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human GlioblastomaLaurent Salphati, Bruno Alicke, Timothy P Heffron, et al.Journal of Medicinal Chemistry|March 29, 2014
Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimizationTerry D Crawford, Chudi O Ndubaku, Huifen Chen, et al.ACS Medicinal Chemistry Letters|August 20, 2015
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal AngiogenesisChudi O Ndubaku, Terry D Crawford, Huifen Chen, et al.Bioorganic & Medicinal Chemistry Letters|May 13, 2014
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2James F Blake, John J Gaudino, Jason De Meese, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|September 21, 2012
Targeting the PI3K pathway in the brain--efficacy of a PI3K inhibitor optimized to cross the blood-brain barrierLaurent Salphati, Timothy P Heffron, Bruno Alicke, et al.Journal of Medicinal Chemistry|February 17, 2012
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic propertiesSimon Mathieu, Stefan N Gradl, Li Ren, et al.Pageof 4