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Science Signaling|September 13, 2018
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumorsThijs J Hagenbeek, Joshua D Webster, Noelyn M Kljavin, et al.Journal of Medicinal Chemistry|May 27, 2016
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical DevelopmentJames F Blake, Michael Burkard, Jocelyn Chan, et al.Nature Communications|August 5, 2023
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumorsAlessandra Castiglioni, Yagai Yang, Katherine Williams, et al.Bioorganic & Medicinal Chemistry Letters|September 1, 2009
GDC-0449-a potent inhibitor of the hedgehog pathwayKirk D Robarge, Shirley A Brunton, Georgette M Castanedo, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious InhibitorsSteve Wenglowsky, Li Ren, Kateri A Ahrendt, et al.Pageof 4