Search research articles
Contact Us
Filters
Showing results (21-30 of 27) with videos related to
Page
of 3
Sort By:
You have reached the last page of results.
This site can display upto 27 results.
Journal of Medicinal Chemistry
|
May 14, 2013
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Chudi O Ndubaku, Timothy P Heffron, Steven T Staben, et al.
Journal of Medicinal Chemistry
|
January 8, 2016
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Timothy P Heffron, Robert A Heald, Chudi Ndubaku, et al.
Journal of Medicinal Chemistry
|
March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Huifen Chen, Matthew Volgraf, Steven Do, et al.
Journal of Medicinal Chemistry
|
September 1, 2012
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
James F Blake, Rui Xu, Josef R Bencsik, et al.
Journal of Medicinal Chemistry
|
February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
Journal of Medicinal Chemistry
|
March 2, 2026
Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C
Nicholas F Endres, Steven Do, Rana Mroue, et al.
Science Signaling
|
June 4, 2020
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Cesar A Corzo, Eugene Varfolomeev, A Francesca Setiadi, et al.
Page
of 3
Search research articles
Search
Showing results (21-30 of 27) with videos related to
Sort By:
Page
of 3
You have reached the last page of results.
This site can display upto 27 results.
Journal of Medicinal Chemistry
|
May 14, 2013
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity
Chudi O Ndubaku, Timothy P Heffron, Steven T Staben, et al.
Journal of Medicinal Chemistry
|
January 8, 2016
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Timothy P Heffron, Robert A Heald, Chudi Ndubaku, et al.
Journal of Medicinal Chemistry
|
March 30, 2018
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Huifen Chen, Matthew Volgraf, Steven Do, et al.
Journal of Medicinal Chemistry
|
September 1, 2012
Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
James F Blake, Rui Xu, Josef R Bencsik, et al.
Journal of Medicinal Chemistry
|
February 5, 2019
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, et al.
Journal of Medicinal Chemistry
|
March 2, 2026
Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C
Nicholas F Endres, Steven Do, Rana Mroue, et al.
Science Signaling
|
June 4, 2020
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells
Cesar A Corzo, Eugene Varfolomeev, A Francesca Setiadi, et al.
Page
of 3