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Frontiers in Pharmacology|July 5, 2022
Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural BiologyAdam C Oken, Ipsita Krishnamurthy, Jonathan C Savage, et al.Science Advances|October 4, 2024
P2X7 receptors exhibit at least three modes of allosteric antagonismAdam C Oken, Ismayn A Ditter, Nicolas E Lisi, et al.Proceedings of the National Academy of Sciences of the United States of America|September 12, 2025
Subtype-specific structural features of the hearing loss-associated human P2X2 receptorFranka G Westermann, Adam C Oken, Philip K E Granith, et al.Nature Communications|August 6, 2024
High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocketAdam C Oken, Nicolas E Lisi, Ipsita Krishnamurthy, et al.Nature Communications|September 15, 2025
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptorAdam C Oken, Andreea L Turcu, Eva Tzortzini, et al.Cell Death & Disease|April 20, 2026
Methodological guidelines for P2X receptor assays and data interpretationDariusz C Gorecki, Elena Adinolfi, Sahil Adriouch, et al.Biorxiv : the Preprint Server for Biology|April 17, 2026
A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathologyAndreea L Turcu, Adam C Oken, Christian Griñán-Ferré, et al.Pageof 2