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Pulmonary Pharmacology & Therapeutics|August 23, 2021
CG223, a novel BET inhibitor, exerts TGF-β1-mediated antifibrotic effects in a murine model of bleomycin-induced pulmonary fibrosisShunya Kaneshita, Takashi Kida, Makoto Yoshioka, et al.
Nature Communications|June 26, 2021
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor functionL Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, et al.
Theranostics|July 21, 2020
Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast CancerAlison K Esser, Michael H Ross, Francesca Fontana, et al.
The Journal of Pharmacology and Experimental Therapeutics|February 19, 2025
First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing propertiesMohan E Tulapurkar, Kari Ann Shirey, Katerina Lugkey, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 16, 2024
First-in-Class Mitogen-Activated Protein Kinase p38α: MAPK-Activated Protein Kinase-2 (MK2) Dual Signal Modulator with Anti-inflammatory and Endothelial-stabilizing PropertiesMohan E Tulapurkar, Kari Ann Shirey, Katerina N Lugkey, et al.
Blood|April 18, 2022
The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasmYong Zhang, Billy Truong, Shawn P Fahl, et al.
Molecular Cancer|May 18, 2013
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with BakXiaobo Cao, Jeremy L Yap, M Karen Newell-Rogers, et al.
Organic & Biomolecular Chemistry|April 30, 2013
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signalingKwan-Young Jung, Ramin Samadani, Jay Chauhan, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|December 23, 2020
VLA4-Targeted Nanoparticles Hijack Cell Adhesion-Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong SurvivalFrancesca Fontana, Michael J Scott, John S Allen, et al.
European Journal of Medicinal Chemistry|March 18, 2016
Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoproteinMaryanna E Lanning, Wenbo Yu, Jeremy L Yap, et al.
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