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Cancer Research|March 21, 2014
Comparative functional analysis of DPYD variants of potential clinical relevance to dihydropyrimidine dehydrogenase activitySteven M Offer, Croix C Fossum, Natalie J Wegner, et al.
Molecular Cancer Therapeutics|January 10, 2014
microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sitesSteven M Offer, Gabriel L Butterfield, Calvin R Jerde, et al.
International Journal of Molecular Sciences|July 27, 2024
Approach for Phased Sequence-Based Genotyping of the Critical Pharmacogene Dihydropyrimidine Dehydrogenase (DPYD)Alisa Ambrodji, Angélique Sadlon, Ursula Amstutz, et al.
Journal of Personalized Medicine|October 22, 2020
A Novel Nomenclature for Repeat Motifs in the Thymidylate Synthase Enhancer Region and Its Relevance for Pharmacogenetic StudiesDominic Schaerer, Tanja K Froehlich, Seid Hamzic, et al.
Cancer Research|September 1, 2016
Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD PromoterRentian Wu, Qian Nie, Erin E Tapper, et al.
British Journal of Clinical Pharmacology|January 25, 2021
Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicitySeid Hamzic, Dominic Schärer, Steven M Offer, et al.
Clinical and Translational Science|December 22, 2023
Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testingAmy J Turner, Cyrine E Haidar, Wenjian Yang, et al.
Genomics, Proteomics & Bioinformatics|September 23, 2021
Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 LabelingXinran Li, Jiaqi Zhou, Wenjuan Zhao, et al.
Clinical Pharmacology and Therapeutics|November 21, 2017
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 UpdateUrsula Amstutz, Linda M Henricks, Steven M Offer, et al.
Elife|April 30, 2024
Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)Ting Zhang, Alisa Ambrodji, Huixing Huang, et al.
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