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Journal of Medicinal Chemistry
|
November 21, 2014
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis
Stephen Brand, Neil R Norcross, Stephen Thompson, et al.
Journal of Medicinal Chemistry
|
June 21, 2023
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, et al.
European Journal of Medicinal Chemistry
|
May 20, 2022
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease
Kate McGonagle, Gary J Tarver, Juan Cantizani, et al.
Nature
|
December 14, 2012
Automated design of ligands to polypharmacological profiles
Jérémy Besnard, Gian Filippo Ruda, Vincent Setola, et al.
Journal of Medicinal Chemistry
|
April 27, 2021
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Michael Thomas, Stephen Brand, Manu De Rycker, et al.
Science Advances
|
September 14, 2022
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, et al.
Cell Reports
|
May 4, 2017
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis
Yasmin M Ramdzan, Mikhail M Trubetskov, Angelique R Ormsby, et al.
Journal of Medicinal Chemistry
|
September 16, 2016
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Beatriz Baragaña, Neil R Norcross, Caroline Wilson, et al.
Journal of Medicinal Chemistry
|
March 18, 2022
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Alasdair Smith, Richard J Wall, Stephen Patterson, et al.
The Journal of Clinical Endocrinology and Metabolism
|
September 8, 2022
Premature Ovarian Insufficiency in CLPB Deficiency: Transcriptomic, Proteomic and Phenotypic Insights
Elena J Tucker, Megan J Baker, Daniella H Hock, et al.
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Search research articles
Search
Showing results (271-280 of 296) with videos related to
Sort By:
Page
of 30
Journal of Medicinal Chemistry
|
November 21, 2014
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis
Stephen Brand, Neil R Norcross, Stephen Thompson, et al.
Journal of Medicinal Chemistry
|
June 21, 2023
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, et al.
European Journal of Medicinal Chemistry
|
May 20, 2022
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease
Kate McGonagle, Gary J Tarver, Juan Cantizani, et al.
Nature
|
December 14, 2012
Automated design of ligands to polypharmacological profiles
Jérémy Besnard, Gian Filippo Ruda, Vincent Setola, et al.
Journal of Medicinal Chemistry
|
April 27, 2021
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Michael Thomas, Stephen Brand, Manu De Rycker, et al.
Science Advances
|
September 14, 2022
Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction
Kenji M Fujihara, Bonnie Z Zhang, Thomas D Jackson, et al.
Cell Reports
|
May 4, 2017
Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis
Yasmin M Ramdzan, Mikhail M Trubetskov, Angelique R Ormsby, et al.
Journal of Medicinal Chemistry
|
September 16, 2016
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Beatriz Baragaña, Neil R Norcross, Caroline Wilson, et al.
Journal of Medicinal Chemistry
|
March 18, 2022
Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis
Alasdair Smith, Richard J Wall, Stephen Patterson, et al.
The Journal of Clinical Endocrinology and Metabolism
|
September 8, 2022
Premature Ovarian Insufficiency in CLPB Deficiency: Transcriptomic, Proteomic and Phenotypic Insights
Elena J Tucker, Megan J Baker, Daniella H Hock, et al.
Page
of 30