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Journal of Medicinal Chemistry|March 27, 2009
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesityPetr Vachal, Joan M Fletcher, Tung M Fong, et al.Bioorganic & Medicinal Chemistry Letters|July 6, 2010
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesityShuwen He, Zhixiong Ye, Peter H Dobbelaar, et al.Proceedings of the National Academy of Sciences of the United States of America|February 28, 2002
Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolismDonald J Marsh, Drew T Weingarth, Dawn E Novi, et al.Journal of Medicinal Chemistry|December 22, 2006
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesityLinus S Lin, Thomas J Lanza, James P Jewell, et al.Bioorganic & Medicinal Chemistry Letters|July 13, 2010
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonistsLiangqin Guo, Zhixiong Ye, Jian Liu, et al.Bioorganic & Medicinal Chemistry Letters|February 13, 2007
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonistsHelen E Armstrong, Amy Galka, Linus S Lin, et al.Journal of Medicinal Chemistry|October 4, 2002
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonistIyassu K Sebhat, William J Martin, Zhixiong Ye, et al.The Journal of Experimental Medicine|August 17, 2005
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in miceAnne Hermanowski-Vosatka, James M Balkovec, Kang Cheng, et al.European Journal of Pharmacology|November 21, 2007
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodentsLauren P Shearman, D Sloan Stribling, Ramon E Camacho, et al.Bioorganic & Medicinal Chemistry Letters|December 8, 2004
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonistBrenda L Palucki, Min K Park, Ravi P Nargund, et al.Pageof 98