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Biorxiv : the Preprint Server for Biology|March 11, 2026
cGAS inhibition delays TDP-43-driven ALS PathogenesisYajing Liu, Weixi Feng, Abulimiti Aikedan, et al.Science (New York, N.Y.)|November 28, 2024
Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelinationChloe Lopez-Lee, Lay Kodama, Li Fan, et al.Biorxiv : the Preprint Server for Biology|February 8, 2024
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy modelGillian K Carling, Li Fan, Nessa R Foxe, et al.Nature Neuroscience|July 29, 2026
cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsyYige Huang, Li Fan, Man Ying Wong, et al.Proceedings of the National Academy of Sciences of the United States of America|September 19, 2012
Synthesis of site-specific antibody-drug conjugates using unnatural amino acidsJun Y Axup, Krishna M Bajjuri, Melissa Ritland, et al.Biorxiv : the Preprint Server for Biology|February 12, 2026
cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsyYige Huang, Li Fan, Man Ying Wong, et al.Immunity|June 24, 2025
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathwaySarah Naguib, Chloe Lopez-Lee, Eileen Ruth Torres, et al.Neuron|October 1, 2024
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy modelGillian K Carling, Li Fan, Nessa R Foxe, et al.Nature Neuroscience|April 24, 2023
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilienceJoe C Udeochu, Sadaf Amin, Yige Huang, et al.Science Translational Medicine|December 1, 2021
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivationFaten A Sayed, Lay Kodama, Li Fan, et al.Pageof 7