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Journal of Medicinal Chemistry|October 14, 2021
Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate InteractionSanjay Bhattarai, Sujan Devkota, Michael S WolfeBiomolecules|July 29, 2025
Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex FormationSujan Devkota, Masato Maesako, Michael S WolfeThe Journal of Biological Chemistry|January 15, 2021
Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residuesSujan Devkota, Todd D Williams, Michael S WolfeElife|February 11, 2025
Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide productionParnian Arafi, Sujan Devkota, Emily Williams, et al.ACS Central Science|July 2, 2020
Mechanisms of γ-Secretase Activation and Substrate ProcessingApurba Bhattarai, Sujan Devkota, Sanjay Bhattarai, et al.Biorxiv : the Preprint Server for Biology|September 11, 2024
Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide productionParnian Arafi, Sujan Devkota, Emily Williams, et al.Communications Biology|February 14, 2023
Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor proteinHung N Do, Sujan Devkota, Apurba Bhattarai, et al.Journal of Molecular Biology|April 29, 2015
Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated PhosphorylationSujan Devkota, Raji E Joseph, Lie Min, et al.Biochemistry|May 19, 2017
An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid RecognitionSujan Devkota, Raji E Joseph, Scott E Boyken, et al.Journal of the American Chemical Society|January 31, 2020
Design of Substrate Transmembrane Mimetics as Structural Probes for γ-SecretaseSanjay Bhattarai, Sujan Devkota, Kathleen M Meneely, et al.Pageof 2