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Theranostics|April 21, 2020
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activationHui-Hui Yang, Jia-Xi Duan, Shao-Kun Liu, et al.
Journal of Medicinal Chemistry|August 1, 2014
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacyKin Sing Stephen Lee, Jun-Yan Liu, Karen M Wagner, et al.
ACS Chemical Neuroscience|December 4, 2023
Synthesis and Preclinical Evaluation of 22-[<sup>18</sup>F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake KineticsMarlon Vincent V Duro, Juno Van Valkenburgh, Diana E Ingles, et al.
Biorxiv : the Preprint Server for Biology|September 5, 2025
Dual Inhibition of sEH and COX-2 Improved Cognition in Alzheimer's Disease via Enhanced Myogenic Response and Cerebral Artery DistensibilityGilbert C Morgan, Andrew Gregory, Chengyun Tang, et al.
Geroscience|February 6, 2026
PTUPB improves cognitive function in Alzheimer's disease associated with enhancing cerebral vascular myogenic response and attenuating vascular remodelingGilbert C Morgan, Andrew Gregory, Chengyun Tang, et al.
Biorxiv : the Preprint Server for Biology|July 28, 2023
Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesisDavid Kim, Tetsuo Horimatsu, Mourad Ogbi, et al.
Geroscience|February 4, 2025
Inhibition of soluble epoxide hydrolase ameliorates cerebral blood flow autoregulation and cognition in alzheimer's disease and diabetes-related dementia rat modelsChengyun Tang, Jane J Border, Huawei Zhang, et al.
Biorxiv : the Preprint Server for Biology|September 11, 2024
Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat ModelsChengyun Tang, Jane J Border, Huawei Zhang, et al.
Communications Biology|March 2, 2026
Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation in miceDavid S Kim, Tetsuo Horimatsu, Mourad Ogbi, et al.
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