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Journal of Medicinal Chemistry|February 27, 2014
Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1Claire Le Manach, Diego Gonzàlez Cabrera, Frederic Douelle, et al.Antimicrobial Agents and Chemotherapy|May 21, 2014
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas diseaseMaria T Bahia, Alvaro F S Nascimento, Ana Lia Mazzeti, et al.Journal of Medicinal Chemistry|May 25, 2017
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal StructuresGeoffrey Schwertz, Matthias C Witschel, Matthias Rottmann, et al.Malaria Journal|June 8, 2011
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in miceGeoffrey S Dow, Erin Milner, Ian Bathurst, et al.Journal of Medicinal Chemistry|August 23, 2014
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of PlasmodiumR Matthew Cross, David L Flanigan, Andrii Monastyrskyi, et al.ACS Omega|April 22, 2022
Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)Yuxiang Dong, Yogesh Sonawane, Steven P Maher, et al.ACS Omega|September 11, 2018
Isoxazolopyrimidine-Based Inhibitors of Sreekanth Kokkonda, Farah El Mazouni, Karen L White, et al.Molecular Cancer Therapeutics|November 6, 2009
CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivoChristopher J Burns, Emmanuelle Fantino, Ian D Phillips, et al.CPT: Pharmacometrics & Systems Pharmacology|August 17, 2023
Development and application of a PBPK modeling strategy to support antimalarial drug developmentNada Abla, Eleanor Howgate, Karen Rowland-Yeo, et al.ACS Infectious Diseases|September 11, 2023
Antimalarial Dibenzannulated Medium-Ring Keto LactamsRongguo Ren, Xiaofang Wang, Derek A Leas, et al.Pageof 18