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Journal of Medicinal Chemistry|March 3, 2020
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer AgentsDaniel L Priebbenow, David J Leaver, Nghi Nguyen, et al.ACS Infectious Diseases|September 20, 2016
A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of MalariaMargaret A Phillips, Karen L White, Sreekanth Kokkonda, et al.Science Translational Medicine|December 13, 2023
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc<sub>1</sub>Stéphanie Braillard, Martine Keenan, Karen J Breese, et al.Cell Death & Disease|March 13, 2021
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumorsChristoph Grohmann, Francesca Walker, Mark Devlin, et al.Journal of Medicinal Chemistry|December 23, 2024
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria ChemopreventionZhe Nie, Roger Bonnert, Jet Tsien, et al.Science Translational Medicine|March 22, 2013
Quinolone-3-diarylethers: a new class of antimalarial drugAaron Nilsen, Alexis N LaCrue, Karen L White, et al.Nature Communications|April 3, 2025
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVIDStefanie M Bader, Dale J Calleja, Shane M Devine, et al.Journal of Medicinal Chemistry|April 20, 2021
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor SeriesMichael J Palmer, Xiaoyi Deng, Shawn Watts, et al.Antimicrobial Agents and Chemotherapy|June 27, 2018
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of MalariaChristel Brunschwig, Nina Lawrence, Dale Taylor, et al.Science Translational Medicine|July 17, 2015
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaMargaret A Phillips, Julie Lotharius, Kennan Marsh, et al.Pageof 18