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Journal of Medicinal Chemistry|September 27, 2018
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite StrainsClaire Le Manach, Tanya Paquet, Kathryn Wicht, et al.Journal of Medicinal Chemistry|May 2, 2022
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis ActivityPreshendren Govender, Rudolf Müller, Kawaljit Singh, et al.ACS Infectious Diseases|December 15, 2020
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein KinasePeter Mubanga Cheuka, Luyanda Centani, Lauren B Arendse, et al.ACS Infectious Diseases|May 30, 2020
Synthesis, Structure-Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial ActivityJessica N Akester, Paul Njaria, Aloysius Nchinda, et al.Antimicrobial Agents and Chemotherapy|March 10, 2022
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to FluoroquinolonesGregory S Basarab, Sandeep Ghorpade, Liezl Gibhard, et al.Journal of Medicinal Chemistry|October 9, 2013
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activityYassir Younis, Frederic Douelle, Diego González Cabrera, et al.European Journal of Medicinal Chemistry|April 17, 2026
Structure-Activity relationship and optimization of drug-like properties of antituberculosis 3-(4,4-dimethyl-1,4-azasilinane)methylpyrazole MmpL3 inhibitorsLutete Peguy Khonde, Nashied Peton, Keabetswe Masike, et al.Plos Neglected Tropical Diseases|September 15, 2022
Drug discovery research in Ghana, challenges, current efforts, and the way forwardRichard Kwamla Amewu, Patrick Amoateng, Patrick Kobina Arthur, et al.Journal of Medicinal Chemistry|December 12, 2022
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection ModelDickson Mambwe, Constance M Korkor, Amanda Mabhula, et al.Journal of Medicinal Chemistry|December 19, 2018
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of MalariaGodfrey Mayoka, Mathew Njoroge, John Okombo, et al.Pageof 31