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Science Translational Medicine|October 19, 2022
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stagesLauren B Arendse, James M Murithi, Tarrick Qahash, et al.Cell Chemical Biology|May 4, 2020
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial ActivityManu Vanaerschot, James M Murithi, Charisse Flerida A Pasaje, et al.Nature Communications|January 12, 2021
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response BoxJanette Reader, Mariëtte E van der Watt, Dale Taylor, et al.ACS Infectious Diseases|March 10, 2018
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion CharacterizationDinakaran Murugesan, Peter C Ray, Tracy Bayliss, et al.Biorxiv : the Preprint Server for Biology|August 12, 2025
The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin FormationKathryn J Wicht, John G Woodland, Larnelle F Garnie, et al.Angewandte Chemie (International Ed. in English)|May 3, 2025
The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against MalariaJohn G Woodland, Dina Coertzen, Kathryn J Wicht, et al.ACS Chemical Biology|June 13, 2026
The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin FormationKathryn J Wicht, John G Woodland, Larnelle F Garnie, et al.Cell Chemical Biology|July 7, 2021
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistanceJames M Murithi, Ioanna Deni, Charisse Flerida A Pasaje, et al.Journal of Medicinal Chemistry|November 18, 2017
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification StudiesColin R Wilson, Richard K Gessner, Atica Moosa, et al.Journal of Medicinal Chemistry|June 25, 2024
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo EfficacyGodwin Akpeko Dziwornu, Donald Seanego, Stephen Fienberg, et al.Pageof 31