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Journal of Medicinal Chemistry|November 30, 2025
Design, Synthesis, and Characterization of Dichlorobiphenyl-Derived Inhibitors of the Proprotein Convertase FurinRoman W Lange, Charlotte Boller, Michael Loresch, et al.Nature Communications|September 2, 2025
Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitorsRupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, et al.Scientific Reports|September 28, 2016
The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformersSven O Dahms, John W M Creemers, Yvonne Schaub, et al.Analytical Chemistry|January 18, 2020
ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion ProteaseWai Tuck Soh, Fatih Demir, Elfriede Dall, et al.Journal of Molecular Biology|January 17, 2012
Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domainSven O Dahms, Ina Könnig, Dirk Roeser, et al.The Journal of Biological Chemistry|July 29, 2020
Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognitionElfriede Dall, Florian B Zauner, Wai Tuck Soh, et al.Antiviral Research|May 30, 2015
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cellsYinghui Lu, Kornelia Hardes, Sven O Dahms, et al.ACS Medicinal Chemistry Letters|March 18, 2021
The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase FurinThuy Van Lam van, Miriam Ruth Heindl, Christine Schlutt, et al.The FEBS Journal|July 22, 2014
Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulansIzabela Sabala, Elzbieta Jagielska, Philip T Bardelang, et al.Chemmedchem|October 24, 2017
Optimization of Substrate-Analogue Furin InhibitorsTeodora Ivanova, Kornelia Hardes, Stephanie Kallis, et al.Pageof 4