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Cancer Research|February 19, 2008
Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycinJoanna L Holmes, Swee Y Sharp, Steve Hobbs, et al.
Plos One|September 18, 2012
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitorsSwee Y Sharp, S Mark Roe, Egidijus Kazlauskas, et al.
Chemistry (Weinheim an Der Bergstrasse, Germany)|January 21, 2010
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90James E H Day, Swee Y Sharp, Martin G Rowlands, et al.
Oncotarget|November 2, 2010
Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibitionMounia Beloueche-Babari, Vaitha Arunan, L Elizabeth Jackson, et al.
Organic & Biomolecular Chemistry|April 2, 2016
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolinesAlpa Patel, Swee Y Sharp, Katelan Hall, et al.
Cancer Research|February 27, 2009
Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cellsNathalie Gaspar, Swee Y Sharp, Simon Pacey, et al.
Molecular Cancer Therapeutics|May 12, 2010
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastomaNathalie Gaspar, Swee Y Sharp, Suzanne A Eccles, et al.
Blood|May 26, 2007
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cellsEmma L Davenport, Hannah E Moore, Alan S Dunlop, et al.
Scientific Reports|September 30, 2020
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approachesJohn F Darby, Lewis R Vidler, Peter J Simpson, et al.
Organic & Biomolecular Chemistry|January 26, 2007
Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycinChristopher S P McErlean, Nicolas Proisy, Christopher J Davis, et al.
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