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Drug Metabolism and Disposition: the Biological Fate of Chemicals|November 14, 2025
The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivoSylvie E Kandel, Jed N LampeChemical Research in Toxicology|April 6, 2021
Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated NeonatesSylvie E Kandel, Jed N LampeChemical Research in Toxicology|August 19, 2014
Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicitySylvie E Kandel, Jed N LampeChemical Research in Toxicology|March 30, 2026
New Mechanistic Evidence for Perfluorodecanoic Acid (PFDA) Teratogenicity via CYP26A1-Mediated Retinoic Acid Metabolism and SignalingMichaela Hvizdak, Sylvie E Kandel, Jed N LampeDrug Metabolism and Disposition: the Biological Fate of Chemicals|October 8, 2025
Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivirAbhinav Pentyala, Sylvie E Kandel, Jed N LampeBioorganic & Medicinal Chemistry Letters|April 15, 2022
Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitorsEmily G Hicks, Sylvie E Kandel, Jed N LampeAnnual Reports in Medicinal Chemistry|March 24, 2015
Cytochrome P450 Enzyme Metabolites in Lead Discovery and DevelopmentSylvie E Kandel, Larry C Wienkers, Jed N LampeDrug Metabolism and Disposition: the Biological Fate of Chemicals|May 3, 2024
Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5Hannah M Work, Sylvie E Kandel, Jed N LampeThe Journal of Biological Chemistry|July 20, 2024
Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1Sylvie E Kandel, Brian C Tooker, Jed N LampeChemical Research in Toxicology|September 28, 2023
Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration ApproachSylvie E Kandel, Emily G Gracey, Jed N LampePageof 2