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Cancer Research|June 1, 1993
Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustardT K Chang, D J WaxmanDrug Metabolism and Disposition: the Biological Fate of Chemicals|September 1, 1994
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levelsT K Chang, H Chen, D J WaxmanThe Journal of Pharmacology and Experimental Therapeutics|July 1, 1995
Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolismT K Chang, G Chen, D J WaxmanArchives of Biochemistry and Biophysics|June 1, 1994
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450T K Chang, F J Gonzalez, D J WaxmanCancer Research|May 15, 1997
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorinesT K Chang, L Yu, P Maurel, et al.The Biochemical Journal|April 15, 1993
The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylationT K Chang, J Teixeira, G Gil, et al.Archives of Biochemistry and Biophysics|July 10, 1995
Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomesA B Rifkind, C Lee, T K Chang, et al.Pharmacogenetics|June 1, 1997
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activationT K Chang, L Yu, J A Goldstein, et al.Cancer Research|December 1, 1993
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomesT K Chang, G F Weber, C L Crespi, et al.The Journal of Endocrinology|September 1, 1996
Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferatorD J WaxmanPageof 23