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Bioorganic & Medicinal Chemistry Letters
|
July 2, 2011
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity
Suzanne S Stokes, Hoan Huynh, Madhusudhan Gowravaram, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 30, 2021
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds
Yousuke Yamada, Kristen Gilliland, Zixiu Xiang, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 8, 2021
Discovery and optimization of a novel CNS penetrant series of mGlu<sub>4</sub> PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
Caitlin N Kent, Mark G Fulton, Kaylee J Stillwell, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 29, 2016
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)
Rocco D Gogliotti, Anna L Blobaum, Ryan M Morrison, et al.
Journal of Medicinal Chemistry
|
May 16, 2014
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region
Sameer P Kawatkar, Thomas A Keating, Nelson B Olivier, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2011
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy
Brian A Sherer, Kenneth Hull, Oluyinka Green, et al.
ACS Chemical Neuroscience
|
July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
Colleen M Niswender, Carrie K Jones, Xin Lin, et al.
Journal of Medicinal Chemistry
|
September 25, 2018
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu<sub>4</sub>)
Sean R Bollinger, Darren W Engers, Joseph D Panarese, et al.
Journal of Medicinal Chemistry
|
September 4, 2015
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Julie L Engers, Alice L Rodriguez, Leah C Konkol, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 15, 2015
Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development
Kerry E Murphy-Benenato, Lakshmaiah Gingipalli, P Ann Boriack-Sjodin, et al.
Page
of 10
Search research articles
Search
Showing results (81-90 of 98) with videos related to
Sort By:
Page
of 10
Bioorganic & Medicinal Chemistry Letters
|
July 2, 2011
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity
Suzanne S Stokes, Hoan Huynh, Madhusudhan Gowravaram, et al.
Bioorganic & Medicinal Chemistry Letters
|
August 30, 2021
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds
Yousuke Yamada, Kristen Gilliland, Zixiu Xiang, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 8, 2021
Discovery and optimization of a novel CNS penetrant series of mGlu<sub>4</sub> PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model
Caitlin N Kent, Mark G Fulton, Kaylee J Stillwell, et al.
Bioorganic & Medicinal Chemistry Letters
|
May 29, 2016
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)
Rocco D Gogliotti, Anna L Blobaum, Ryan M Morrison, et al.
Journal of Medicinal Chemistry
|
May 16, 2014
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region
Sameer P Kawatkar, Thomas A Keating, Nelson B Olivier, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2011
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy
Brian A Sherer, Kenneth Hull, Oluyinka Green, et al.
ACS Chemical Neuroscience
|
July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
Colleen M Niswender, Carrie K Jones, Xin Lin, et al.
Journal of Medicinal Chemistry
|
September 25, 2018
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu<sub>4</sub>)
Sean R Bollinger, Darren W Engers, Joseph D Panarese, et al.
Journal of Medicinal Chemistry
|
September 4, 2015
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
Julie L Engers, Alice L Rodriguez, Leah C Konkol, et al.
Bioorganic & Medicinal Chemistry Letters
|
October 15, 2015
Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development
Kerry E Murphy-Benenato, Lakshmaiah Gingipalli, P Ann Boriack-Sjodin, et al.
Page
of 10