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Nature Communications|June 3, 2024
Potent activity of polymyxin B is associated with long-lived super-stoichiometric accumulation mediated by weak-affinity binding to lipid AKerry R Buchholz, Mike Reichelt, Matthew C Johnson, et al.ACS Infectious Diseases|April 10, 2024
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug TargetJacob T Rutherford, Kristiana Avad, Chetna Dureja, et al.Antimicrobial Agents and Chemotherapy|January 24, 2024
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategyChetna Dureja, Jacob T Rutherford, Fahad B A Pavel, et al.Biorxiv : the Preprint Server for Biology|October 4, 2023
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategyChetna Dureja, Jacob T Rutherford, Fahad B A Pavel, et al.Bioorganic & Medicinal Chemistry|May 24, 2023
Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agentsKrissada Norseeda, Fahad Bin Aziz Pavel, Jacob T Rutherford, et al.Journal of Molecular Biology|February 15, 2008
Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulationCatherine E Vrentas, Tamas Gaal, Melanie B Berkmen, et al.FEBS Letters|February 16, 1999
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovirM S Bennett, F Wien, J N Champness, et al.Cell|January 13, 2015
A qrr noncoding RNA deploys four different regulatory mechanisms to optimize quorum-sensing dynamicsLihui Feng, Steven T Rutherford, Kai Papenfort, et al.Clinical Pharmacology and Therapeutics|March 3, 2007
Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategiesM A Andrew, T R Easterling, D B Carr, et al.Oncogene|April 15, 2008
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cellsR Chen, A B Alvero, D A Silasi, et al.Pageof 7