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Human Molecular Genetics|April 21, 2011
Tissue-specific demethylation in CpG-poor promoters during cellular differentiationGenta Nagae, Takayuki Isagawa, Nobuaki Shiraki, et al.Nature Communications|November 19, 2017
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesisEwelina Krzywinska, Chahrazade Kantari-Mimoun, Yann Kerdiles, et al.Proceedings of the National Academy of Sciences of the United States of America|June 10, 2020
A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activationYukiteru Nakayama, Katsuhito Fujiu, Ryuzaburo Yuki, et al.Cancer Science|December 11, 2025
A Transcriptomic Analysis of Cancer-Stromal Interactome in Lung Cancer Xenograft ModelsYuriko Takayama-Isagawa, Daisuke Komura, Takayuki Isagawa, et al.European Heart Journal Open|January 26, 2026
Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF modelDaigo Sawaki, Takayuki Isagawa, Shigeru Sato, et al.The Journal of Biological Chemistry|November 13, 2025
LPS induces limited activation of hypoxia-inducible factor-1α in macrophagesTakayuki Isagawa, Masaki Suimye Morioka, Hiroaki Semba, et al.Nature Communications|June 29, 2019
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin MHajime Abe, Norihiko Takeda, Takayuki Isagawa, et al.Genome Research|December 14, 2011
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiencyLinghua Wang, Shuichi Tsutsumi, Tokuichi Kawaguchi, et al.Journal of Pharmacological Sciences|March 8, 2026
Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metaboliteTatsuyuki Sato, Takayuki Isagawa, Yuki Sugiura, et al.Nature Metabolism|May 31, 2024
PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activityHiroki Sekine, Haruna Takeda, Norihiko Takeda, et al.Pageof 6