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Bioorganic & Medicinal Chemistry|August 4, 2022
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activityTomoyoshi Imaizumi, Michinori Akaiwa, Tomoaki Abe, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|September 1, 2004
High-level in vivo gene marking after gene-modified autologous hematopoietic stem cell transplantation without marrow conditioning in nonhuman primatesKyoji Ueda, Yutaka Hanazono, Hiroaki Shibata, et al.
Bioorganic & Medicinal Chemistry|January 4, 2024
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumorsTomoyoshi Imaizumi, Itsuro Shimada, Yoshiki Satake, et al.
Molecular Cancer Therapeutics|March 26, 2025
Enhanced Antitumor Immunity by ASP1570, a Novel Diacylglycerol Kinase ζ Inhibitor, Offers a Potential Novel Immunotherapy for Treating CancerOsamu Ikeda, Aya Kikuchi, Hirofumi Tsuzuki, et al.
Communications Chemistry|August 23, 2025
Discovery of KRAS(G12D) selective degrader ASP3082Tomohiro Yoshinari, Takeyuki Nagashima, Hiroki Ishioka, et al.
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