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Molecular Metabolism|December 14, 2025
Long-acting GIPR agonist LY3537021 reduces body weight and fasting blood glucose in patients with T2D: Preclinical development and phase 1 randomized ascending dose studiesWilliam Roell, Jorge Alsina-Fernandez, Hongchang Qu, et al.Cardiovascular Research|October 8, 2019
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis developmentEnchen Zhou, Geerte Hoeke, Zhuang Li, et al.Cell Metabolism|January 11, 2023
Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonistOlivier Benichou, Tamer Coskun, Malgorzata D Gonciarz, et al.Cell Metabolism|April 9, 2025
Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidationEric Ravussin, Guillermo Sanchez-Delgado, Corby K Martin, et al.Journal of the Endocrine Society|July 10, 2019
Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male MiceBrandy Snider, Andrea Geiser, Xiao-Peng Yu, et al.Plos One|March 29, 2013
Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319Alexei Kharitonenkov, John M Beals, Radmila Micanovic, et al.Elife|July 30, 2020
The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signallingAmy A Worth, Rosemary Shoop, Katie Tye, et al.Molecular Metabolism|November 27, 2018
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of conceptTamer Coskun, Kyle W Sloop, Corina Loghin, et al.Diabetes|May 2, 2022
GIPR Agonism Inhibits PYY-Induced Nausea-Like BehaviorRicardo J Samms, Richard Cosgrove, Brandy M Snider, et al.Nature Medicine|June 24, 2025
Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trialCorby K Martin, Owen T Carmichael, Susan Carnell, et al.Pageof 10