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Journal of Medicinal Chemistry|September 11, 2024
Tuning RXR Modulators for PGC1α RecruitmentFelix Nawa, Minh Sai, Jan Vietor, et al.Journal of Medicinal Chemistry|May 8, 2025
A First-in-Class Hepatocyte Nuclear Factor 4 AgonistEspen Schallmayer, Vasily Morozov, Silke Duensing-Kropp, et al.Angewandte Chemie (International Ed. in English)|May 11, 2026
An Agonist/Antagonist Photo-Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDRXiu Ge, Sabine Willems, Francesco Melfi, et al.Journal of the American Chemical Society|February 25, 2026
Hydrophobic Refinement of Polarity-Switchable Lipo-Xenopeptides Modulates Endosomal Escape and Enhances mRNA Delivery In Vitro and In VivoTobias Burghardt, Sophie Thalmayr, Lennart Obeser, et al.Journal of Medicinal Chemistry|December 8, 2023
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist PotencyGustave Adouvi, Felix Nawa, Marco Ballarotto, et al.Journal of the American Chemical Society|June 29, 2023
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ ModulationSilvia Arifi, Julian A Marschner, Julius Pollinger, et al.Nature Communications|September 11, 2024
Automated design of multi-target ligands by generative deep learningLaura Isigkeit, Tim Hörmann, Espen Schallmayer, et al.Antiviral Research|June 16, 2025
RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP traffickingSameh A Gad, Doaa A Abo Elwafa, Saied A Hussein, et al.ACS Chemical Biology|November 1, 2022
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective ModulatorsJan Heering, Nathalie Jores, Whitney Kilu, et al.Journal of the American Chemical Society|August 4, 2025
Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular WeightSabrina Toews, Francesca Donà, Marco Keller, et al.Pageof 16