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Nature Communications|April 11, 2026
Structural optimization of drug molecules with incrementally trained language modelsTim Hörmann, Domenic Mayer, Max Lewandowski, et al.Biochemical Pharmacology|May 27, 2019
A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in miceMd Abdul Hye Khan, Jurema Schmidt, Anna Stavniichuk, et al.Journal of Medicinal Chemistry|October 23, 2025
Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor ModulatorsNils Christiaan Bandomir, Tim Hörmann, Annette Kärcher, et al.Future Medicinal Chemistry|January 30, 2016
SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compoundChristina Lamers, Daniel Merk, Matthias Gabler, et al.International Journal of Molecular Sciences|September 9, 2022
Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor AgonistsMoritz Helmstädter, Simone Schierle, Laura Isigkeit, et al.Frontiers in Immunology|January 18, 2024
Dual soluble epoxide hydrolase inhibitor - farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosisMd Abdul Hye Khan, Benjamin Nolan, Anna Stavniichuk, et al.Communications Chemistry|January 27, 2023
The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugsSabine Willems, Whitney Kilu, Xiaomin Ni, et al.Journal of Medicinal Chemistry|July 21, 2020
Design and Structural Optimization of Dual FXR/PPARδ ActivatorsSimone Schierle, Sebastian Neumann, Pascal Heitel, et al.International Journal of Molecular Sciences|November 14, 2020
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR IsoformsApirat Chaikuad, Julius Pollinger, Michael Rühl, et al.Journal of Medicinal Chemistry|January 6, 2022
Design of a Potent TLX Agonist by Rational Fragment FusionGiuseppe Faudone, Rezart Zhubi, Fatih Celik, et al.Pageof 16