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Communications Chemistry|May 21, 2025
Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand designÚrsula López-García, Jan Vietor, Julian A Marschner, et al.Journal of Medicinal Chemistry|September 26, 2014
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonistDaniel Merk, Christina Lamers, Khalil Ahmad, et al.Journal of Medicinal Chemistry|June 24, 2021
Second-Generation Dual FXR/sEH Modulators with Optimized PharmacokineticsMoritz Helmstädter, Astrid Kaiser, Steffen Brunst, et al.Journal of Medicinal Chemistry|January 28, 2026
Systematic Optimization of Fragment TLX Ligands toward Agonism and Inverse AgonismEmily C Hank, Loris Knümann, Úrsula López-García, et al.Journal of Medicinal Chemistry|November 9, 2018
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)David Heidenreich, Moses Moustakim, Jurema Schmidt, et al.Journal of Medicinal Chemistry|September 18, 2025
Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed ScaffoldXiu Ge, Till Kasch, Max Lewandowski, et al.Scientific Reports|September 12, 2018
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitroPascal Heitel, Leonie Gellrich, Jan Heering, et al.Science Advances|June 12, 2021
Combining generative artificial intelligence and on-chip synthesis for de novo drug designFrancesca Grisoni, Berend J H Huisman, Alexander L Button, et al.Journal of Medicinal Chemistry|December 19, 2022
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγGustave Adouvi, Laura Isigkeit, Úrsula López-García, et al.Chemmedchem|March 10, 2023
Development of Light-Activated LXR AgonistsTufan K Mukhopadhyay, Sabine Willems, Christopher J Arp, et al.Pageof 16